Our Research

Our research group focuses on Bioinformatics and Systems Biology applications in vaccine and infectious diseases research. Our research interests are highly interdisciplinary including computer science, biomedical sciences, public health and immunology. We also have a special focus in software tools and database systems development.

Overview of our research. We have three different research themes 1) Systems vaccinology, 2) Systems immunology and 3) Computational methods and resources development.

Systems Immunology

This research plan is driven by the main goal of applying a systems immunology framework to decipher the intricate dynamics underlying host-pathogen relationships. The primary objectives are to elucidate emergent properties within infectious disease systems, construct predictive models that capture the complex interplay between pathogens and hosts, and identify actionable targets for vaccination and/or therapeutic interventions. By harnessing the power of comprehensive systems biology advanced computational methodologies, we aim to enhance the understanding of infectious diseases and transform this knowledge into tangible medical advancements.

Systems Vaccinology

The central objective of this research program is to leverage systems vaccinology approaches to advance the rational development of vaccines against challenging pathogens. By integrating multi-omics data and applying modern machine learning algorithms, we aim to contribute to advancing the understanding of each step in the vaccine development chain (predicting responses, understand mode of action, propose new immune modulators, assess vaccine safety). Finally, our mission is to support the creation of novel vaccines and optimize existing ones to combat infectious diseases that impact human and animal life.

Computational methods and resources development

In line with the core mission of VIDO to combat infectious diseases and advance global health, this research project seeks to harness the power of bioinformatics to bolster the understanding, prevention, and control of infectious diseases affecting both humans and animals. This will be done through the development of advanced computational methods, user-friendly software tools, and comprehensive online resources that enhance the efficiency and effectiveness of pathogen characterization, immunological response analysis, and epidemiological investigations.